Decoding the antibody repertoire : high throughput sequencing of multiple transcripts from single b cells

• Main Author: DeKosky, Brandon (Author)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer, 2017.
• Series: Springer theses.
• Subjects: B cells > Research.; Immunoglobulins > Analysis.; elektronické knihy; electronic books
• ISBN: 9783319585185; 9783319585178
• Physical Description: 1 online resource

This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new te...