Variants of TRAF2 which act as an inhibitor of TNF-alpha (TNFα) signaling pathway

The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF α signaling pathway. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as "TRAF2 truncated" or "TRAF2TR" and a TRAF2 expression construct wi...

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Bibliographic Details
Main Authors Searfoss, III, George H, Pagnoni, Marco F, Ivashchenko, Yuri D, Guo, Kun, Clark, Kenneth L
Format Patent
LanguageEnglish
Published 19.02.2008
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Summary:The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF α signaling pathway. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as "TRAF2 truncated" or "TRAF2TR" and a TRAF2 expression construct with enhanced dominant negative properties, hereafter referred to as "TRAF2 truncated-deleted" or "TRAF2TD". Both TRAF2TR and TRAF2TD have the ability to inhibit the TNF α signaling pathway and in TRAF2TD, this ability is greatly enhanced, greatly reducing the response to TNF α binding.