NOVEL PEROXIREDOXIN DEFENSE SYSTEM FROM MYCOBACTERIUM TUBERCULOSIS
Mycobacterium tuberculosisMycobacterium tuberculosis Mycobacterium tuberculosis The present invention relates to methods of preventing and treating tuberculosis in a subject infected with . The method involves inhibiting AhpD in the subject under conditions effective to make the pathogen susceptible...
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| Format | Patent |
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| Language | English |
| Published |
02.05.2007
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| Online Access | Get full text |
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| Summary: | Mycobacterium tuberculosisMycobacterium tuberculosis Mycobacterium tuberculosis The present invention relates to methods of preventing and treating tuberculosis in a subject infected with . The method involves inhibiting AhpD in the subject under conditions effective to make the pathogen susceptible to antimicrobial reactive nitrogen intermediates or reactive oxygen intermediates. The present invention also relates to methods of preventing and treating tuberculosis in a subject infected with involving inhibiting dihydrolipoamide dehydrogenase or dihydrolipoamide succinyltransferase in in the subject under conditions effective to make the pathogen susceptible to antimicrobial reactive nitrogen intermediates or reactive oxygen intermediates. Also disclosed are methods for identifying candidate compounds suitable for treatment or prevention of tuberculosis. Methods of producing an AhpD crystal suitable for X-ray diffraction as well as methods for designing a compound suitable for treatment or prevention of tuberculosis and compounds suitable for treatment or prevention of tuberculosis are also disclosed. |
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