Functional assessment of hepatobiliary secretion by 11 C-cholylsarcosine positron emission tomography

• Published in: Biochimica et biophysica acta. Molecular basis of disease Vol. 1864; no. 4 Pt B; p. 1240
• Main Authors: Ørntoft, Nikolaj, Frisch, Kim, Ott, Peter, Keiding, Susanne, Sørensen, Michael
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2018
• Subjects: Anti-Bacterial Agents - adverse effects; Bile Acids and Salts - metabolism; Bile Ducts - diagnostic imaging; Bile Ducts - metabolism; Carbon Radioisotopes - administration & dosage; Carbon Radioisotopes - chemistry; Chemical and Drug Induced Liver Injury - diagnostic imaging; Chemical and Drug Induced Liver Injury - etiology; Cholestasis - diagnostic imaging; Cholestasis - etiology; Cholic Acids - administration & dosage; Cholic Acids - chemistry; Feasibility Studies; Female; Humans; Liver - diagnostic imaging; Liver - metabolism; Liver - pathology; Middle Aged; Molecular Imaging - methods; Pneumonia - drug therapy; Positron-Emission Tomography - methods; Radioactive Tracers; Sarcosine - administration & dosage; Sarcosine - analogs & derivatives; Sarcosine - chemistry; Hepatic transport kinetics; Bile acid transport; Drug-induced liver injury; Functional molecular imaging of the liver; Cholestasis
• ISSN: 0925-4439
• DOI: 10.1016/j.bbadis.2017.11.016

Positron emission tomography (PET) with C-cholylsarcosine ( C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.