Tree shrew (Tupaia belangeri) as a novel non-human primate laboratory disease animal model

The tree shrew (Tupaia belangeri) is a promising laboratory animal that possesses a closer genetic relationship to primates than to rodents. In addition, advantages such as small size, easy breeding, and rapid reproduction make the tree shrew an ideal subject for the study of human disease. Numerous...

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Bibliographic Details
Published inDōngwùxué yánjiū Vol. 38; no. 3; p. 127
Main Authors Xiao, Ji, Liu, Rong, Chen, Ce-Shi
Format Journal Article
LanguageEnglish
Published Kunming Kunming Institute of Zoology, The Chinese Academy of Sciences 01.05.2017
Subjects
Animal diseases
Animal models
Biomedical research
Breeding
Diseases
Disorders
Drug abuse
Drug addiction
Genetic relationship
Human diseases
Infectious diseases
Laboratory animals
Mental depression
Metabolic disorders
Myopia
Primates
Rodents
Small mammals
Transgenic animals
Tupaia belangeri
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ISSN0254-5853
DOI10.24272/j.issn.2095-8137.2017.033

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Summary:The tree shrew (Tupaia belangeri) is a promising laboratory animal that possesses a closer genetic relationship to primates than to rodents. In addition, advantages such as small size, easy breeding, and rapid reproduction make the tree shrew an ideal subject for the study of human disease. Numerous tree shrew disease models have been generated in biological and medical studies in recent years. Here we summarize current tree shrew disease models, including models of infectious diseases, cancers, depressive disorders, drug addiction, myopia, metabolic diseases, and immune-related diseases. With the success of tree shrew transgenic technology, this species will be increasingly used in biological and medical studies in the future.
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ISSN:0254-5853
DOI:10.24272/j.issn.2095-8137.2017.033