Parasite Load Decrease during Application of a Safe and Easily Applied Antileishmanial Aminoglycoside Cream e2749

[...]a protocol amendment was approved to recruit and randomize eight additional subjects, establishing a total population of 48. [...]a total of 48 Tunisian adults with parasitologically positive CL ulcers were randomized 1:1 to receive WR 279,396 with either a polyurethane or gauze-and-tape dressi...

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Published inPLoS neglected tropical diseases Vol. 8; no. 5
Main Authors Salah, Afif Ben, Zaâtour, Amor, Messaoud, Nathalie Ben, Kidar, Abdelhamid, Smith, Philip L, Kopydlowski, Karen M, Kreishman-Deitrick, Mara, Nielsen, Carl J, Novitt-Moreno, Anne, Ransom, Janet H, Morizot, Gloria, Grogl, Max, Buffet, Pierre A
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 01.05.2014
Subjects
Colleges & universities
Laboratory tests
Load
Parasites
Parasitic diseases
Toxicity
Tropical diseases
Ulcers
Online AccessGet full text
ISSN1935-2727
1935-2735
DOI10.1371/journal.pntd.0002749

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Summary:[...]a protocol amendment was approved to recruit and randomize eight additional subjects, establishing a total population of 48. [...]a total of 48 Tunisian adults with parasitologically positive CL ulcers were randomized 1:1 to receive WR 279,396 with either a polyurethane or gauze-and-tape dressing. WR 279,396 is well tolerated. Since it causes no systemic toxicity, WR 279,396 can be administered without the need for clinical laboratory testing/monitoring.
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ISSN:1935-2727
1935-2735
DOI:10.1371/journal.pntd.0002749