소아의 메타콜린 기관지유발검사에서 PC20-FEF25%-75% 및 △FVC에 대한 분석
Purpose: Forced expiratory flow between 25% and 75% (FEF25%–75%) is known to sensitively reflect bronchial obstruction. Methacholine challenge test (MCT) has shown varying reduction levels of forced vital capacity (FVC) with the reduction in forced expiratory volume in 1 second (FEV1) in asthma. The...
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Published in | Allergy asthma & respiratory disease pp. 141 - 147 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | Korean |
Published |
대한 소아알레르기 호흡기학회
01.07.2021
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Subjects | |
Online Access | Get full text |
ISSN | 2288-0402 2288-0410 |
DOI | 10.4168/aard.2021.9.3.141 |
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Summary: | Purpose: Forced expiratory flow between 25% and 75% (FEF25%–75%) is known to sensitively reflect bronchial obstruction. Methacholine challenge test (MCT) has shown varying reduction levels of forced vital capacity (FVC) with the reduction in forced expiratory volume in 1 second (FEV1) in asthma. The aim of this study was to evaluate the clinical implication of provocative concentration causing a 20% fall in FEF25%–75% (PC20-FEF25%–75%) and the percentage fall in FVC at the PC20 dose of methacholine (△FVC).
Methods: A total of 194 children who visited the hospital due to respiratory symptoms and underwent MCT were analyzed retrospectively. The patients were divided into 3 groups. Group I had both PC20-FEV1 and PC20-FEF25%–75% above 16 mg/mL; group II had a PC20-FEF25%–75% that fell below 16 mg/mL but PC20-FEV1 was 16 mg/mL or above; group III had a PC20-FEV1 and a PC20-FEF25%–75% that both fell below 16 mg/mL.
Results: In group II, PC20-FEV1 was lower (P=0.026) and the rate of change in FEV1 and FEF25%–75% from baseline to 16 mg/mL of methacholine concentration was greater than in group I (both P<0.001). Levels of PC20-FEF25%–75% were higher in group II compared to group III (P<0.001). △FVC showed a correlation with PC20-FEV1 (P<0.001) only in the whole group.
Conclusion: In asthmatic children, PC20-FEF25%–75% may be associated with bronchial hyperresponsiveness. △FVC was not associated with other parameters in either group. For subjects with a positive finding of PC20-FEF25%–75% and a negative finding of MCT, the progression to asthma can be suspected. KCI Citation Count: 0 |
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ISSN: | 2288-0402 2288-0410 |
DOI: | 10.4168/aard.2021.9.3.141 |