Preparation/characterization of solid dispersions and enhancement of dissolution rate on celecoxib as BCS II class
Celecoxib with low solubility and high permeability (BCS class II) in water is a non-steroidal anti-inflammatory drug used in the treatment of pain and inflammation, associated with rheumatoid arthritis, and several other inflammatory disorders. Also, it is a selective cyclooxygenase 2 inhibitor wit...
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Published in | Journal of pharmaceutical investigation p. 399 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
한국약제학회
01.10.2014
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Subjects | |
Online Access | Get full text |
ISSN | 2093-5552 2093-6214 |
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Summary: | Celecoxib with low solubility and high permeability (BCS class II) in water is a non-steroidal anti-inflammatory drug used in the treatment of pain and inflammation, associated with rheumatoid arthritis, and several other inflammatory disorders. Also, it is a selective cyclooxygenase 2 inhibitor with low water solubility and high crystallinity. The objective of this study was to improve dissolution rate of celecoxib which was water-insoluble drug. Solid dispersions were prepared by spray drying as the solvent evaporation method. The dissolution behavior of solid dispersions was compared with Celebrex® (Pfizer) as a control group in simulated gastric juice (pH 1.2, 0.5 % SLS. The characterization of the prepared solid dispersions is analyzed by scanning electron microscope, powder X-ray diffractometer, Fourier transform infrared spectroscopy and reverse phase-high performance liquid chromatography The best formulation was SD 8 in this study. It was the cumulative release of 97 % at 120 min. This study suggests that the solubility and bioavailability of poorly water-soluble celecoxib improved through the prepared solid dispersions by spray drying method. KCI Citation Count: 0 |
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Bibliography: | G704-000166.2014.44.5.002 |
ISSN: | 2093-5552 2093-6214 |