Continuous Renal Replacement Therapy in a 4-year-old Child with Rhabdomyolysis Following Parainfluenza Virus Infection and Hyperammonemia due to Isovaleric Acidemia

• Published in: Childhood kidney diseases pp. 132 - 136
• Main Authors: 박세진, 조수연, 배기수, 신재일
• Format: Journal Article
• Language: English
• Published: 대한소아신장학회 01.10.2013
• Subjects: 소아과학
• ISSN: 2384-0242; 2384-0250

Parainfluenza virus infection is one of the causes of fatal rhabdomyolysis. Rhabdomyolysis can be aggravated by mitochondrial fatty acid β-oxidation disorders during prolonged periods of fasting. Moreover, in patients with late-onset isovaleric acidemia, hyperammonemia may occur following catabolic stress. In the present report, we describe a case of a 4-year-old boy with parainfluenza virus infection and late-onset isovaleric acidemia that rapidly progressed to coma,seizures, and cardiorespiratory collapse. His serum ammonia and creatinine kinase (CK) levels were 385 μMol/L and 23,707 IU/L, respectively. Continuous renal replacement therapy (CRRT) was initiated using continuous venovenous hemodiafiltration, after which the ammonia and CK levels returned to normal. Thus, we recommend the immediate initiation of CRRT in the management of patients with life-threatening rhabdomyolysis and hyperammonemia. KCI Citation Count: 0