원발성 침윤성 소엽암종으로 오진한 유방으로 전이된 갑상샘 수질암종 - 1예 보고

• Published in: Journal of pathology and translational medicine pp. 412 - 415
• Main Authors: 이영석, 안정석, 김철환, 염범우, 최종상, 채양석
• Format: Journal Article
• Language: Korean
• Published: 대한병리학회 01.12.2007
• Subjects: 병리학
• ISSN: 2383-7837; 2383-7845

Metastasis to the breast from medullary carcinoma of the thyroid is extremely rare. We report a case of metastatic medullary carcinoma of the thyroid which presented as multiple breast masses with ipsilateral axillary lymphadenopathy in a 48-year-old woman. Six years ago, she underwent total thyroidectomy and neck dissection because of palpable neck masses, with a diagnosis of medullary thyroid carcinoma. Histological features of breast masses showed single- file or linear-cord arrangements, with plasmacytoid appearance, and the initial diagnosis was invasive lobular carcinoma. She underwent modified radical mastectomy. The tumor cells were diffusely positive for E-cadherin, calcitonin and thyroid transcription factor-1 (TTF-1) and were metastatic medullary carcinoma of thyroid. In the patients with a history of medullary carcinoma of the thyroid, a careful examination is necessary for a breast mass composed of solid and cord-like clusters of small round to ovoid cells with plasmacytoid appearance. Immunohistochemical staining for E-cadherin, calcitonin and TTF-1 could be helpful for differential diagnosis. KCI Citation Count: 1