Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Korean Women: A Multicenter Study

Background : DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods : A total of 2,368 women from five regions of the country underwent Pap smear examinat...

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Published inJournal of pathology and translational medicine pp. 342 - 350
Main Authors 홍성란, 김인선, 김동원, 김미진, 김애리, 김영옥, 김혜선, 나서희, 박경신, 박용구, 박용욱, 박호성, 서광선, 손진희, 신미경, 오훈규, 윤기중, 윤혜경, 이시내, 이아원, 이효진, 최찬, 정운원
Format Journal Article
LanguageEnglish
Published 대한병리학회 01.08.2009
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ISSN2383-7837
2383-7845

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Summary:Background : DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods : A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing. Results : Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. Highrisk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma. Conclusions : The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening. KCI Citation Count: 9
Bibliography:http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0357920090430040342
G704-000333.2009.43.4.007
ISSN:2383-7837
2383-7845