자연 경과에 따른 만성 B형 간염의 간조직 내 FoxP3 양성 조절 T세포의 침윤 양상: 간 침생검 조직을 이용한 면역 조직 화학적 연구
Background : Regulatory T cells (Tregs) may contribute to the immunological hyporesponsiveness against hepatitis B virus (HBV), and this can result in chronic infection. Tregs suppress the T cell responses directed against HBV and they protect hepatocytes by down-regulating the immune responses that...
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Published in | Journal of pathology and translational medicine pp. 132 - 140 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | Korean |
Published |
대한병리학회
01.04.2010
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Subjects | |
Online Access | Get full text |
ISSN | 2383-7837 2383-7845 |
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Summary: | Background : Regulatory T cells (Tregs) may contribute to the immunological hyporesponsiveness against hepatitis B virus (HBV), and this can result in chronic infection. Tregs suppress the T cell responses directed against HBV and they protect hepatocytes by down-regulating the immune responses that cause liver damage, but the role of Tregs has not been well characterized. Methods : Fifty four patients were selected and classified into three groups (12 were in the immune-tolerance phase, 35 were in the immune-clearance phase and 7 were in the asymptomatic virus carrier phase). We examined the frequency of CD3+, CD4+ & CD8+T cells and forkhead box P3 (FoxP3)+ Tregs in the needle-biopsied liver tissue by performing immunohistochemistry. Results : The FoxP3+ Tregs were mainly located at the portal tracts. In the immune-clearance phase, the frequency of FoxP3+ Tregs was significantly increased compared to that of the immune-tolerance group and the asymptomatic carrier group. Increased FoxP3+ T cells were observed in the patients with a higher histologic inflammatory index. No correlation was observed among the numbers of FoxP3+ Tregs, the serum alanine aminotransferase level, detection of HBeAg and the HBV-DNA viral load. Conclusions : FoxP3+ Tregs may play important roles in suppressing the immune response to HBV and the complete elimination of HBV.
Background : Regulatory T cells (Tregs) may contribute to the immunological hyporesponsiveness against hepatitis B virus (HBV), and this can result in chronic infection. Tregs suppress the T cell responses directed against HBV and they protect hepatocytes by down-regulating the immune responses that cause liver damage, but the role of Tregs has not been well characterized. Methods : Fifty four patients were selected and classified into three groups (12 were in the immune-tolerance phase, 35 were in the immune-clearance phase and 7 were in the asymptomatic virus carrier phase). We examined the frequency of CD3+, CD4+ & CD8+T cells and forkhead box P3 (FoxP3)+ Tregs in the needle-biopsied liver tissue by performing immunohistochemistry. Results : The FoxP3+ Tregs were mainly located at the portal tracts. In the immune-clearance phase, the frequency of FoxP3+ Tregs was significantly increased compared to that of the immune-tolerance group and the asymptomatic carrier group. Increased FoxP3+ T cells were observed in the patients with a higher histologic inflammatory index. No correlation was observed among the numbers of FoxP3+ Tregs, the serum alanine aminotransferase level, detection of HBeAg and the HBV-DNA viral load. Conclusions : FoxP3+ Tregs may play important roles in suppressing the immune response to HBV and the complete elimination of HBV. KCI Citation Count: 1 |
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Bibliography: | G704-000333.2010.44.2.012 http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0357920100440020132 |
ISSN: | 2383-7837 2383-7845 |