중추성 요붕증과 뇌하수체 기능부전으로 나타난 뇌하수체 전이성 유방암 1예

• Published in: Endocrinology and metabolism (Seoul) pp. 125 - 129
• Main Authors: 곽재욱, 지병수, 홍순화, 김지현, 이승환, 조재형, 권혁상, 윤건호, 차봉연, 손호영
• Format: Journal Article
• Language: Korean
• Published: 대한내분비학회 01.04.2007
• Subjects: 내과학
• ISSN: 2093-596X; 2093-5978

저자들은 다음, 다뇨 및 야뇨의 증상을 호소한 환자에서 완전 중추성 요붕증 및 뇌하수체 기능부전을 진단하고 이를 통하여 유방암의 뇌하수체 전이를 확인한 국내 첫 번째 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Metastasis to the pituitary gland from systemic cancer is a rare condition. The breast and lung are the most common sites of primary tumor metastasis. Pituitary metastasis may present with diabetes insipidus, cranial nerve palsy and hypopituitarism, and diabetes insipidus is the most frequent symptom at presentation. We report here on a 44 year-old woman with pituitary metastasis from breast cancer, and she developed central diabetes insipidus and hypopituitarism. The clinical diagnosis was made by performing a water deprivation test, a combined pituitary test and a MRI brain scan, and the latter showed metastatic tumor in the pituitary gland with invasion of the pituitary stalk. Symptomatic relief was obtained with administration of desmopressin; the urine osmolarity was increased with this treatment.We report here on a case of pituitary metastasis from breast cancer and the patient developed central diabetes insipidus and hypopituitarism. We also include a review of the relevant literature. (J Kor Endocrine Soc 22:125~129, 2007) KCI Citation Count: 1