The Effect of Substance P on Nasal Mucosal Hypersensitivity through Sensory Nerve Axonal Reflex

• Published in: Journal of rhinology pp. 38 - 42
• Main Authors: 조중생, 장도영, 이동엽, 홍남표, 안회영
• Format: Journal Article
• Language: English
• Published: 대한비과학회 01.05.1997
• Subjects: 이비인후과학
• ISSN: 1229-1498; 2384-4361

The mucus secretion of airway glands is known to be controlled by the various autonomic neurotransmitters such as noradrenalinand acetylcholine. However, a recent study suggests that non-adrenergic, non-cholinergic (NANC) nerves may contributeto the secretory activity of glands. Substance P (SP) has been proposed as a neurotransmitter of the NANC nervoussystem. SP is present within nerve fibers innervating the airway mucosa and is known to be released from sensory nerves via anaxonal reflex. SP activity is controlled by neutral endopeptidase (NEP) which degrades SP. In this study, we evaluated theeffects of NEP inhibitor (thiorphan) and substance P on nasal mucosa and histamine on the nasal mucosa in healthy males. Inthe thiorphan-substance P experimental group, the nasal volume decreased after nebulization of substance P in proportion to theconcentration of histamine. In the thiorphan-substance P experimental group, the frequency of sneezing increased in proportionto the concentration of histamine, but there was no increased frequency of sneezing from thiorphan, SP and normal saline. Theresults of this study suggest that axonal reflexes can play a role in the pathogenesis of nasal mucosal hypersensitivity andneurogenic inflammation. KCI Citation Count: 0