Nasal Hyperreactivity to Methacholine Test in Perennial Allergic Rhinitis

• Published in: Journal of rhinology pp. 34 - 39
• Main Authors: 조중생, 이건희, 김훈, 유영인, 차창일
• Format: Journal Article
• Language: English
• Published: 대한비과학회 01.05.2001
• Subjects: 이비인후과학
• ISSN: 1229-1498; 2384-4361

Although histamine and methacholine challenge tests are commonly used to evaluate the hypersensitivity in allergicrhinitis, some controversies still remain to standardize the test. This study was designed to evaluate the usefulness of themethacholine challenge test for the evaluation of hyperreactivity in allergic rhinitis. Twenty three patients with perennialallergic rhinitis and 17 normal subjects were included in this study. All subjects underwent saline nasal challenge andmethacholine nasal challenge test with different doses (6 mg, 12 mg, 24 mg / in 0.5 ml of saline). We measured the nasalcavity volume by acoustic rhinometry in each step and counted the number of sneezes for 15 minutes. The volume of nasalsecretion was also measured by tissue paper method. Besides that, we compared the data between allergic patients with ashort (under 1 year) and long duration (more than 1 year). There were no differences in the frequency of sneezing andnasal volume change to each amount of methacholine in both groups. Nasal secretion increased after methacholine challengein both groups. However, the allergic group showed significant increase after the methacholine challenge of 12 mg comparedto the control group. And the volume of nasal secretion significantly increased in patients with a long duration. The nasalmethacholine challenge test can be used as a diagnostic tool to detect hyperreactivity in perennial allergic rhintis. The optimaldilution was 12 mg (in 0.5 ml of saline) for the nasal methacholine challenge test. KCI Citation Count: 0