Various CC Chemokine in Nasal Polyps and the Effect on CC Chemokine by Antibiotic Treatment

• Published in: Journal of rhinology pp. 11 - 15
• Main Authors: 여승근, 조중생, 차창일, 윤상원
• Format: Journal Article
• Language: English
• Published: 대한비과학회 01.05.2001
• Subjects: 이비인후과학
• ISSN: 1229-1498; 2384-4361

Background and Objectives：The cause of nasal polyp is unsure but inflammation is thought to be an important factor inthe development of nasal poyps. CC chemokine is a powerful chemotactic cytokine for inflammatory cells. We designed thisstudy to investigate whether specific CC chemokines are associated with different forms of nasal polyps and their changesaccording to antibiotic treatment. Materials and Methods：Nasal polyp from patients with atopy (AP group, n=12) andwithout atopy (NP group, n=20) were sampled. Expressions of RANTES, eotaxin, MCP-2, MCP-3 and MIP-1α werestudied by an immunohistochemical study. Specimens of non-allergic nasal turbinates were used as the control group from 14patients who were operated for nasal blockage. All patients were divided into 2 groups. One group was treated with antibioticsfor 10 days before operation. The other was non-treated. Results：Between the NP and AP group, the ratio of stainedcells except anti-MCP 2 monoclonal antibody in the AP group was more increased than that of the NP group. Among them,RANTES and eotaxin were increased significantly (p<0.05). There was a significant difference of the expression of 5 CCchemokines between the treated and non-treated groups (p<0.05). Conclusions：These results suggest that chemokinesplay an important role in the development of nasal polyps, and different kinds of chemokines can be involved according tothe cause of nasal polyps and CC chemokines affected by antibiotic treatment. KCI Citation Count: 0