The Effect of Leukotriene D₄on the Patency of Nasal Passage in Guinea Pigs

• Published in: Journal of rhinology pp. 104 - 109
• Main Authors: 조중생, 차장일, Kotaro Ukai, Yasuo Sakakura
• Format: Journal Article
• Language: English
• Published: 대한비과학회 01.11.1995
• Subjects: 이비인후과학
• ISSN: 1229-1498; 2384-4361

Acoustic reflections have been used in adult human to determine nasal cavity dimension in terms of cross sectional area as a function of the distance from nostril. In order to measure nasal cavity dimensions in guinea pigs, we modified equipment for use in human by decreasing sound tube dimension, increasing sampling frequency, and applying a special nosepiece. The percent change of volume (VOL) from the nostril to 2cm into the nasal cavity showed significant reduction at 30 minutes and 6 hours after instillation of LTD₄ in guinea pigs. However the guinea pig instilled saline did not show any change in VOL. This result indicated that leukotriene was an potent mediator to induce nasal obstruction of late reaction in guinea pig. KCI Citation Count: 0