Mast Cells and Allergic Rhinitis

• Published in: Journal of rhinology pp. 85 - 91
• Main Author: 조중생
• Format: Journal Article
• Language: English
• Published: 대한비과학회 01.11.1998
• Subjects: 이비인후과학
• ISSN: 1229-1498; 2384-4361

That mast cells play a role in acute allergic inflammation by releasing various inflammatory mediators, including histamine,leukotrienes (LT), such as LTC4 and LTD4, and prostaglandins (PG), such as PGD2, is well known. Additionally, mast cellscontribute to the development of allergic inflammation also through the release of multifunctional cytokines. The incidence ofintraepithelial mast cells (IEMC) is found to be greater in nasal mucosa exposed to an allergen, and the cells are thought to play animportant role in producing the immediate allergic reaction. Lamina propira mast cells (LPMC) are known to be the dominantsource of TH2 cytokine and are responsible for development of the late phases of an allergic reaction They may upregulate theexpression of adhesion molecules on the endothelial cells and induce basophil and eosinophil recruitment. Based on these considerationit can be proposed that mast cell is a initiating cell of allergic reaction in target organ and IEMC and LPMC havecapacity to make major contribution to both immediate or late phase reaction of allergic rhinitis. KCI Citation Count: 0