ABO 혈액형과 감염성 질병 검사의 연관성

• Published in: Taehan Suhyŏl Hakhoe chi pp. 113 - 122
• Main Authors: 장해봉, 김상경, 이아진, 서헌석, 전창호, 안호성
• Format: Journal Article
• Language: Korean
• Published: 대한수혈학회 01.09.2014
• Subjects: 임상병리학
• ISSN: 1226-9336; 2383-6881

Background: The distribution of ABO and Rhesus D (RhD) blood group antigens differs according to race andregion. Previous studies have reported that blood group type was associated with not only transfusion-relateddiseases but also various diseases, such as malignancy and infectious disease. However, true relationship of bloodgroups and many diseases remained controversial. The aim of this study was to determine whether ABO and RhDblood groups are correlated with several infectious diseases. Methods: From January 2003 to December 2012, we retrospectively reviewed results for HBsAg, HCV Ab, HIVAb, VDRL, HAV IgM, CMV IgM, EBV VCA IgM, and Clostridium difficile toxin A and B (CD toxin). Wealso reviewed ABO and RhD results of these patients. Data were analyzed using chi-square test and binary logisticregression test. Odds ratio and 95% confidence intervals were determined. Results: A total of 109,898 medical records of ABO and HBsAg results were reviewed. Blood group type-A wasmore prone to have positive results with HBsAg, while blood group type-O was less affected (odds ratio 1.086,P=0.003, odds ratio 0.935, P=0.029, respectively). With 3,171 records of CD toxin, blood group type-O was moreaffected (odds ratio 1.247, P=0.027). The relationship of the other serologic results and blood groups was notstatistically significant. Conclusion: Seroprevalence of HBsAg and CD toxin showed an association with blood group type. Blood grouptype-A had higher HBsAg seroprevalence than the other group. Blood group type-O was more prone to have CDtoxin. KCI Citation Count: 0