Prognostic Factors for Distant Metastasis in Patients with Loco-regional Recurrence after Mastectomy

• Published in: Journal of breast cancer pp. 279 - 284
• Main Authors: 정유리, 김수산, 공경엽, 이희진, 안세현, 손병호, 이종원, 최은경, 이상욱, 안승도
• Format: Journal Article
• Language: English
• Published: 한국유방암학회 01.09.2015
• Subjects: 일반외과학
• ISSN: 1738-6756; 2092-9900

Purpose: The purpose of this study was to identify patients with high risk of distant metastasis (DM) after salvage treatment for postmastectomy locoregional recurrence (LRR). Methods: We retrospectively reviewed 142 patients who received salvage radiotherapy with or without wide excision for isolated LRR after mastectomy between January 1999 and December 2012. Distant metastasis-free survival (DMFS) was estimated from the date of diagnosis of isolated LRR to the date of DM or last follow-up using the Kaplan-Meier method, and Cox regression analysis was performed to identify prognostic factors for DM. Results: The median follow-up period was 54 months. The major failure pattern was DM (56%) and the 5-year DMFS was 43%. In multivariate analysis, initial N (iN) stage, recurrent N (rN) stage, and hormone receptor (HR) status were significant prognostic factors for DM (5-year DMFS: iN0 vs. iN1-3, 73% vs. 25%, p<0.001; rN0 vs. rN1-3, 61% vs. 29%, p<0.001; HR+ vs. HR–, 49% vs. 21%, p<0.001). Conclusion: Patients with lymph node involvement and/or HR– specimens seem to experience more DM than patients with chest wall-only recurrence and HR+ specimens. Further studies are needed to investigate the role of chemotherapy in these patients. KCI Citation Count: 3