급성기 뇌졸중 환자에서 Brain Natriuretic Peptide가 갖는 예후 인자적 가치

• Published in: Kosin Medical Journal (Online) pp. 123 - 130
• Main Author: 이지현
• Format: Journal Article
• Language: Korean
• Published: 고신대학교 의과대학 학술지 01.06.2009
• Subjects: 의학일반
• ISSN: 2005-9531; 2586-7024

Background: Brain Natriuretic Peptide (BNP) Brain natriuretic peptides (BNP) has provided prognostic information in various patient populations especially in heart failure and coronary syndromes. However, the prognostic value of BNP among patients with acute stroke remains unclear, although elevated peptide levels have occasionally been observed. We measured plasma BNP at admission in acute ischemic stroke patients without evident cardiac disease. We compaired the relationship between plasma BNP level and the course of clinical neurological deficits. s Methods : A series of 75 patients (mean age, 64.0 ± 11.0 years) in acute ischemic stroke without evident cardiac disease underwent a comprehensive clinical examination and measurements of plasma BNP at admission in the acute phase of stroke. The relation of laboratory values to risk factors for all-cause mortality, stroke subtype classification, clinical course, and outcome after 30 days were analyzed. Control group was consisted of 31 subjects without neurological focal deficits. s Results : Plasma concentrations of BNP (124.7 ± 209.1 pg/ml) in the stroke patients were significantly higher than those of the healthy subjects (39.1 ± 27.7 pg/ml, P <0.018, respectively). The proportion of patients with bad outcome was increased significantly in the group with high BNP level. Using univariate regression analysis, significant relation of BNP to morbidity and mortality found in acute ischemic stroke patients. n Conclusion : Plasma levels of BNP were elevated in the acute phase of stroke and predict clinical outcome including poststroke mortality. KCI Citation Count: 0