배양된 기도 상피세포에서 종양괴사인자에 의한 IκB의 분해와 NF-κB p65의핵으로의 이동에 미치는 실리비닌과 레스베라트롤의 영향

• Published in: Yaghag-hoi-ji pp. 1 - 6
• Main Authors: 박수현, 이현재, 류지호, 이수열, 신현대, 홍장희, 석정호, 이충재
• Format: Journal Article
• Language: Korean
• Published: 대한약학회 01.02.2014
• Subjects: 약학
• ISSN: 0377-9556; 2383-9457

We examined whether silibinin and resveratrol affect airway mucin production, degradation of IκB and translocationof NF-κB p65 induced by TNF-α in NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulatedwith TNF-α for 24 h or the indicated periods. The two compounds suppressed TNF-α-induced airway mucinproduction, degradation of IκB and translocation of NF-κB p65. This result suggests that silibinin and resveratrol can regulatethe production of mucin induced by TNF-α through the inactivation of NF-κB pathway in airway epithelial cells. KCI Citation Count: 5