Association of FOXJ1 polymorphisms with systemic lupuserythematosus and rheumatoid arthritis in Korean population

• Published in: Experimental & molecular medicine pp. 805 - 811
• Main Authors: Chun-Shi Li, Qinggao Zhang, 임미경, 신동혁, 심승철, Ji-Young Kim, 이신석, Ki-Jung Yun, Hyung-Bae Moon, 정헌택, 채수천
• Format: Journal Article
• Language: English
• Published: 생화학분자생물학회 01.12.2007
• Subjects: 생화학
• ISSN: 1226-3613; 2092-6413

The forkhead-box J1 (FOXJ1) transcription factor could suppress a spontaneous activation of T cells and κBβ that results in re-pression of NF-κB activity. In Foxj1 deficiency mice, systemic autoimune inflamation is quite comon symptom. Therefore, deregulated Foxj1 is suposed to be associated with autoimmune diseases and/or other inflammatory diseases. Previously, we identified that polymorphisms of human FOXJ1 gene (g.460C＞T, g.1805G＞T and g.3375G＞C) are associated with al-lergic rhinitis in a Korean population. In present study, we compared the genotype and allele frequencies of these SNPs between healthy controls and systemic lu-pus erythematosus (SLE) or rheumatoid arthritis (RA) patients. We also investigated the relationships be-twen each genotype and the expression levels of anti- nuclear antibodies in SLE patients, and rheumatoid patients. The frequencies of haplotypes constructed by these FOXJ1 SNPs were compared between con-trols and SLE (or RA) patients. The results of genotype and allele analysis showed that the prevalence of poly-morphism g.3375G＞C was associated with the sus-ceptibility of SLE (P = 0.0072 and 0.0042, respectively). But no significant association was found with RA. In the haplotype analysis, however, the main CGG patients (P = 0.048). KCI Citation Count: 18