A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis

• Published in: Experimental & molecular medicine pp. 1 - 9
• Main Authors: 박성민, 박성준, 김희진, 권오형, 강태욱, 손현암, 김선규, 노성무, 송규상, 장세진, 김선영
• Format: Journal Article
• Language: English
• Published: 생화학분자생물학회 01.07.2013
• Subjects: 생화학
• ISSN: 1226-3613; 2092-6413

Long intergenic non-coding RNAs (lincRNAs) have historically been ignored in cancer biology. However, thousands of lincRNAs have been identified in mammals using recently developed genomic tools, including microarray and high-throughput RNA sequencing (RNA-seq). Several of the lincRNAs identified have been well characterized for their functions in carcinogenesis. Here we performed RNA-seq experiments comparing gastric cancer with normal tissues to find differentially expressed transcripts in intergenic regions. By analyzing our own RNA-seq and public microarray data, we identified 31 transcripts,including a known expressed sequence tag, BM742401. BM742401 was downregulated in cancer, and its downregulation was associated with poor survival in gastric cancer patients. Ectopic overexpression of BM742401 inhibited metastasis-related phenotypes and decreased the concentration of extracellular MMP9. These results suggest that BM742401 is a potential lincRNA marker and therapeutic target. KCI Citation Count: 41