ENDOTHELIN INTERMEDIAETES BY ASYMMETRIC CONJUGATE ADDITION REACTION USING A CHIRAL ADDITIVE

• Main Authors: TILLYER, RICHARD D, TSCHAEN, DAVID M, XU, FENG
• Format: Patent
• Language: English
• Published: 19.06.2002
• Subjects: APPARATUS THEREFOR; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL METHODS OF ORGANIC CHEMISTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

This invention relates to a process for the preparation of a key intermediate in the synthesis of an endothelin antagonist, having formula (I) by using a chiral additive to effect an asymmetric conjugate addition. Ovaj pronalazak se odnosi na postupak za dobijanje ključnog intermedijara u sintezi endotelin antagonista, koji ima formulu (I) upotrebljavajući hiralni aditiv da bi se ostvarila asimetrična konjugovana adicija.[This invention relates to a process for the preparation of a key intermediate in the synthesis of an endothelin antagonist, having formula (I) by using a chiral additive to effect an asymmetric conjugate addition.