PROCESS FOR THE PREPARATION OF A QUINAZOLINONE DERIVATIVE

The present invention relates to a new process for the preparation of (3R)-N-[2-cyano-4- fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide, as well as to a novel intermediate useful for the synthesis of said compound at large scale. La présente invention concern...

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Bibliographic Details
Main Authors SEDELMEIER, Joerg, DOTT, Pascal, MODOLOLLAT, Isabelle Huguette, LARI, Giacomo Marco, FANTASIA, Serena Maria, TROKOWSKI, Sebastian, GUILLEMOT-PLASS, Maud, KALDRE, Dainis
Format Patent
LanguageEnglish
French
Published 20.06.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a new process for the preparation of (3R)-N-[2-cyano-4- fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide, as well as to a novel intermediate useful for the synthesis of said compound at large scale. La présente invention concerne un nouveau procédé de préparation de (3R)-N-[2-cyano-4-fluoro-3-(3-méthyl-4-oxo-quinazolin-6-yl)oxy-phényl]-3-fluoro-pyrrolidine-1-sulfonamide, ainsi qu'un nouvel intermédiaire utile pour la synthèse dudit composé à grande échelle.
Bibliography:Application Number: WO2023EP85728