PIKFYVE INHIBITOR COMBINATION THERAPY

Provided herein are methods of treating a neurological disease or disorder (e.g., ALS) comprising administering PIKfyve inhibitor (e.g., any PIKfyve inhibitors known or described herein, including but not limited to APY0201, YM201636, or a pharmaceutically acceptable salt thereof), or a pharmaceutic...

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Bibliographic Details
Main Authors SPIRLI, Carlo, YOUNG, Peter Ronald
Format Patent
LanguageEnglish
French
Published 06.06.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are methods of treating a neurological disease or disorder (e.g., ALS) comprising administering PIKfyve inhibitor (e.g., any PIKfyve inhibitors known or described herein, including but not limited to APY0201, YM201636, or a pharmaceutically acceptable salt thereof), or a pharmaceutically acceptable salt thereof and an antioxidant (e.g., edaravone). In some embodiments, further therapeutic agents (e.g., glutamatergic agents) are administered to the subject. La présente invention concerne des méthodes de traitement d'une maladie ou d'un trouble neurologique (p. ex. SLA) consistant à administrer un inhibiteur de PIKfyve (p. ex. tout inhibiteur de PIKfyve connu ou décrit dans la présente invention, comprenant non exclusivement APY0201, YM201636, ou un sel pharmaceutiquement acceptable correspondant), ou un sel pharmaceutiquement acceptable correspondant et un antioxydant (p. ex. édaravone). Dans certains modes de réalisation, d'autres agents thérapeutiques (p. ex. des agents glutamatergiques) sont administrés au sujet.
Bibliography:Application Number: WO2023US81184