이중대립유전자성 기능 상실 또는 유전자 과발현 돌연변이를 갖는 암을 치료하는 방법

• Main Authors: RIMKUNAS VICTORIA, GLODZIK DOMINIK, KOEHLER MARIA, ZINDA MICHAEL, DABER ROBERT, REIS JORGE SERGIO, SILVERMAN IAN
• Format: Patent
• Language: Korean
• Published: 08.02.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

이중대립유전자성 ATM 기능 상실 돌연변이를 갖는 암을 치료하는 방법이 개시된다. 또한, 이중대립유전자성 ATM 기능 상실 돌연변이를 갖는 암 세포에서 세포 사멸을 유도하는 방법이 개시된다. 이러한 방법은 전형적으로, 유효량의 ATR 억제제를 이를 필요로 하는 대상체에 투여하거나 이중대립유전자성 ATM 기능 상실 돌연변이를 갖는 암 세포를 ATR 억제제와 접촉시키는 단계를 포함한다. 또한, CCNE1이 증폭된 암을 치료하는 방법이 개시된다. Methods of treating cancers having a biallelic ATM loss of function mutation are disclosed. Also disclosed are methods of inducing cell death in cancer cells having a biallelic ATM loss of function mutation. The methods typically include administering to the subject in need thereof an effective amount of an ATR inhibitor or contacting the cancer cell having a biallelic ATM loss of function mutation with an ATR inhibitor. Also disclosed are methods of treating cancers amplified for CCNE1.