薬物送達における粘膜吸引パッチ及びその使用

• Format: Patent
• Language: Japanese
• Published: 11.11.2024
• Subjects: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

本開示は、薬物を含有する少なくとも１つのバルブを含む粘膜吸引パッチであって、弾性を有する少なくとも１つのバルブが、圧力印加表面に機械的圧力を印加すると、少なくとも１つのバルブが変形し、パッチ封止表面が対象粘膜上にある間に機械的圧力が解放されるとき、少なくとも１つのバルブが、その膨張状態を少なくとも部分的に回復し、次いで、粘膜を変形させ、これが少なくとも１つのバルブキャビティの少なくとも一部を可逆的に充填し、薬物を粘膜内に移動させる、粘膜吸引パッチを提供する。対象における薬物の経粘膜送達のためのパッチの使用もまた提供する。このパッチは、薬物、特に巨大分子薬物の非侵襲的、非注射全身投与を可能にする。 The present disclosure provides a mucosal suction patch comprising at least one bulb containing a drug; the at least one bulb having an elasticity such that, upon applying mechanical pressure on a pressure applying surface of the patch, the at least one bulb is deformed, and when the mechanical pressure is released while the patch sealing surface is on a subject mucosa, the at least one bulb at least partially regains its expanded state, which in turn deforms the mucosa, which reversibly fills up at least part of the at least one bulb cavity, causing the drug to migrate in the mucosa. It also provides uses of the patch for the transmucosal delivery of a drug in a subject. This patch enables a non-invasive, non-parenteral systemic administration of drugs, particularly macromolecular drugs.