TREATMENT OF GASTROINTESTINAL BLEEDING IN PATIENTS WITH SEVERE VON WILLEBRAND DISEASE BY ADMINISTRATION OF RECOMBINANT VWF

To provide a novel method for treating gastrointestinal bleeding in a subject with severe von Willebrand Disease (VWD).SOLUTION: The present invention relates to a method for treating gastrointestinal bleeding in a subject with severe von Willebrand Disease (VWD), comprising administering to the sub...

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Bibliographic Details
Main Authors BETTINA PLODER, MIRANDA CHAPMAN, BRUCE EWENSTEIN
Format Patent
LanguageEnglish
Japanese
Published 05.09.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a novel method for treating gastrointestinal bleeding in a subject with severe von Willebrand Disease (VWD).SOLUTION: The present invention relates to a method for treating gastrointestinal bleeding in a subject with severe von Willebrand Disease (VWD), comprising administering to the subject at least one dose of recombinant von Willebrand Factor (rVWF) ranging from about 40 IU/kg to about 100 IU/kg, wherein the first dose further comprises recombinant Factor VIII (rFVIII).SELECTED DRAWING: Figure 1 【課題】重度のフォンヴィレブランド病（ＶＷＤ）を患う患者において消化管出血を治療するための新規方法を提供する。【解決手段】重度のフォンヴィレブランド病（ＶＷＤ）を患う対象に、４０ＩＵ／ｋｇ～約１００ＩＵ／ｋｇの範囲の少なくとも１用量の組換えフォンヴィレブランド因子（ｒＶＷＦ）を投与することを含む、前記対象において消化管出血を治療するための方法であって、第１の用量が、組換え第ＶＩＩＩ因子（ｒＦＶＩＩＩ）をさらに含む、前記方法である。【選択図】図１
Bibliography:Application Number: JP20230106554