骨髄非破壊性前処置のための組成物および方法

• Format: Patent
• Language: Japanese
• Published: 30.03.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

【課題】骨髄非破壊性前処置のための組成物および方法の提供。【解決手段】本明細書には、ＣＤ３４受容体、ＣＤ４５受容体、またはＣＤ１１７受容体等の細胞表面マーカーを標的とする骨髄非破壊性抗体－毒素コンジュゲートおよび組成物、およびそれらを使用して、生着または移植の前に対象の組織（例えば、骨髄組織）を有効に前処置するための関連方法が開示されている。本明細書で開示されている組成物および方法は、例えば造血幹細胞移植の前に対象の組織を前処置するために使用することができ、有利なことには、そのような組成物および方法は、従来の前処置法に一般に伴う毒性を引き起こさない。【選択図】なし Disclosed herein are non-myeloablative antibody-toxin conjugates and compositions that target cell surface markers, such as the CD34, CD45 or CD117 receptors, and related methods of their use to effectively conditioning a subject's tissues (e.g., bone marrow tissue) prior to engraftment or transplant. The compositions and methods disclosed herein may be used to condition a subject's tissues in advance of, for example, hematopoietic stem cell transplant and advantageously such compositions and methods do not cause the toxicities that are commonly associated with traditional conditioning methods.