羅漢果抽出物を有効成分として含有する呼吸器疾患の予防、改善、または治療用組成物

• Format: Patent
• Language: Japanese
• Published: 21.10.2021
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

本発明は、羅漢果残渣抽出物を有効成分として含有する呼吸器疾患の予防、改善、または治療用組成物に関するものであって、本発明の羅漢果残渣抽出物は、卵白アルブミン(OVA)で誘導された喘息動物モデルにおいて気道過敏性減少、気管支肺胞洗浄液内の炎症細胞抑制及び気管支肺胞洗浄液内のTh2サイトカイン(IL-4、IL-5、及びIL-13)減少、肺組織の炎症及び組織損傷減少、気道平滑筋収縮及び気道炎症抑制効果、肺組織でIL-13、TARC、TNF-a、IL-17、及び粘液遺伝子MUC5ACの発現抑制効果、微細ホコリによって増加した肺胞細胞でのROSを減少させる効果がある。 A method for or treating respiratory disease according to an embodiment includes administering to a subject in need thereof an extract of Siraitia grosvenorii residuals as an effective component. The extract of Siraitia grosvenorii residuals has, in an animal model having asthma induced by ovalbumin (OVA), an effect of reducing airway hyper-responsiveness, inhibiting inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing Th2 cytokines (IL-4, IL-5, and IL-13) in BALF, reducing inflammation and tissue damage in lung tissues, inhibiting contraction of airway smooth muscle and airway inflammation, an effect of inhibiting expression of IL-13, TARC, TNF-α, IL-17, and MUC5AC, which is a gene encoding mucus protein, in lung tissues, an effect of reducing the level of ovalbumin-specific IgE in blood serum, and an effect of reducing ROS in alveolar cells which is generated in excess amount due to fine dust.