USE OF BACTERIA, BACTERIAL PRODUCTS AND OTHER IMMUNOREGULATORY ENTITIES IN COMBINATION WITH ANTI-CTLA-4 AND/OR ANTI-PD-1 ANTIBODIES TO TREAT SOLID TUMOR MALIGNANCIES

• Main Authors: KENNETH KINZLER, KIM KIBEM, ZHOU SHIBIN, BERT VOGELSTEIN, SAURABH SAHA
• Format: Patent
• Language: English; Japanese
• Published: 02.07.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide methods and kits for treating solid tumors in a subject by using a combination of anti-CTLA-4 and/or anti-PD-1 antibodies with at least one member of the group consisting of bacteria, bacterial products, and immunoregulatory entities.SOLUTION: In particular embodiments, the bacteria are toxin-depleted, anaerobic bacteria, such as Clostridium novyi-NT. In one aspect, the invention provides a method for treating a solid tumor in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one antibody selected from the group consisting of an anti-CTLA-4 antibody and an anti-PD-1 antibody in combination with at least one member of the group consisting of bacteria, bacterial products, and immunoregulatory entities, thereby treating the solid tumor.SELECTED DRAWING: None 【課題】抗ＣＴＬＡ−４および／または抗ＰＤ−１抗体と、細菌、細菌産物、および免疫調節性実体からなる群の少なくとも１つのメンバーの組み合わせを使用することにより、被験体において固形腫瘍を処置するための方法およびキットを提供すること。【解決手段】特定の実施形態では、細菌はＣｌｏｓｔｒｉｄｉｕｍ ｎｏｖｙｉ−ＮＴなどの毒素枯渇嫌気性細菌である。一局面において、被験体において固形腫瘍を処置するための方法が提供され、この方法は、上記被験体に、抗ＣＴＬＡ−４抗体および抗ＰＤ−１抗体からなる群より選択される少なくとも１つの抗体の治療有効量を、細菌、細菌産物、および免疫調節性実体からなる群の少なくとも１つのメンバーと組み合わせて投与して、上記固形腫瘍を処置することを含む。【選択図】なし