METHOD OF ASSISTING DETECTION OF BREAST CANCER, POLYPEPTIDE PROBE SET, AND POLYNUCLEOTIDE ARRAY

• Main Authors: SAHAR SIBANI, NIROSHAN RAMACHANDRAN, KAREN SUE ANDERSON, JOSHUA LABAER, GARRICK WALLSTROM
• Format: Patent
• Language: English; Japanese
• Published: 02.08.2018
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a method of assisting detection of breast cancer.SOLUTION: A method comprises the steps of: (a) contacting a suitable bodily fluid sample obtained from a subject having a risk of breast cancer with one or more isolated polypeptides selected from a group consisting of GPR157 and antigenic fragments thereof, arbitrarily, PDCD6IP, DBT, CSNK1E, FRS3, RAC3, HOXD1, SF3A1, C15orf48, MYOZ2, EIF3E, BAT4, ATF3, BMX, RAB5A, UBAP1, SOX2, BDNF, ZMYM6, SLC33A1, TRIM32, ALG10, TFCP2, SERPINH1, SELL, ZNF510, and antigenic fragments thereof under suitable conditions; and (b) detecting presence of antibodies to the polypeptides in the bodily fluid sample. Presence of antibodies to the polypeptides indicates a likelihood of the breast cancer in the subject.SELECTED DRAWING: None 【課題】乳がんの検出を補助する方法を提供する。【解決手段】方法は、（ａ）乳がんのリスクを有する対象者から得られた適切な体液試料を、ＧＰＲ１５７またはその抗原性フラグメントと、任意にＰＤＣＤ６ＩＰ、ＤＢＴ、ＣＳＮＫ１Ｅ、ＦＲＳ３、ＲＡＣ３、ＨＯＸＤ１、ＳＦ３Ａ１、Ｃ１５ｏｒｆ４８、ＭＹＯＺ２、ＥＩＦ３Ｅ、ＢＡＴ４、ＡＴＦ３、ＢＭＸ、ＲＡＢ５Ａ、ＵＢＡＰ１、ＳＯＸ２、ＢＤＮＦ、ＺＭＹＭ６、ＳＬＣ３３Ａ１、ＴＲＩＭ３２、ＡＬＧ１０、ＴＦＣＰ２、ＳＥＲＰＩＮＨ１、ＳＥＬＬ、ＺＮＦ５１０、及びこれらの抗原性フラグメントから選択された１つ以上の単離ポリペプチドと適切な条件下で接触させるステップと、（ｂ）体液試料中における前記ポリペプチドに対する抗体の存在を検出するステップとを含み、前記ポリペプチドに対する抗体の存在は対象者における乳がんの可能性を示す。【選択図】なし