炎症性肝疾患の診断のための方法および組成物

• Format: Patent
• Language: Japanese
• Published: 03.12.2015
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

本開示は、対象における炎症性肝疾患の診断を促進することにおける使用をみいだす方法および組成物を提供する。方法および組成物は、概して、エオタキシン-３（Ｅ３）レベルを単独で、またはエオタキシン-１（Ｅ１）のレベルとともに、および任意にＣＣＬ２２のレベルとともに、およびさらに任意にＩＬ１５のレベルとともに、検出することを伴う。これらのレベルは、自己免疫性肝炎（ＡＩＨ）、原発性胆汁性肝硬変（ＰＢＣ）、および原発性硬化性胆管炎（ＰＳＣ）のうちの少なくとも１つの肝疾患の診断を促進し、および／またはＡＩＨ、ＰＢＣ、およびＰＳＣ間の鑑別診断を促進するために使用され得る。本開示の方法および組成物は、また、対象についての治療の決定を促進することにおける使用をみいだす。【選択図】なし The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.