基于γ-δT细胞细胞外囊泡的肿瘤疫苗的组合物和方法

已经发现γδ-T-细胞外囊泡(EV)具有促进DC成熟的免疫佐剂效应，该效应通过与γδ-T-EV相关的IFN-γ介导。提供了包括衍生自γδ-T细胞(γδ-T-EV)的细胞外囊泡(EV)的无细胞组合物及其使用方法。γδ-T-EV可与肿瘤相关抗原(TAA)或肽库结合或包封它们以形成γδ-T-EV疫苗组合物。γδ-T-EV组合物可用作癌症免疫疗法中的佐剂，或者γδ-T-EV疫苗组合物可在有需要的受试者中诱导肿瘤特异性T细胞应答并直接杀伤肿瘤细胞。 It has been discovered that γδ-T-extracellular vesicles (EV) have immune adjuv...

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Bibliographic Details
Format Patent
LanguageChinese
Published 19.09.2025
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:已经发现γδ-T-细胞外囊泡(EV)具有促进DC成熟的免疫佐剂效应，该效应通过与γδ-T-EV相关的IFN-γ介导。提供了包括衍生自γδ-T细胞(γδ-T-EV)的细胞外囊泡(EV)的无细胞组合物及其使用方法。γδ-T-EV可与肿瘤相关抗原(TAA)或肽库结合或包封它们以形成γδ-T-EV疫苗组合物。γδ-T-EV组合物可用作癌症免疫疗法中的佐剂，或者γδ-T-EV疫苗组合物可在有需要的受试者中诱导肿瘤特异性T细胞应答并直接杀伤肿瘤细胞。 It has been discovered that γδ-T-extracellular vesicles (EV) have immune adjuvant effects that promote DCs maturation, mediated by the IFN-γ associated with the γδ-T-EVs. Cell-free compositions including extracellular vesicles (EVs) derived from γδ-T cells (γδ-T-EVs) and methods of use thereof are provided. The γδ-T-EVs can associated with or encapsulate tumor-associated antigens (TAAs) or peptide pools to form a γδ-T-EV vaccine composition. γδ-T-EVs compositions can be used as adjuvants in cancer immunotherapy or the γδ-T-EV vaccine compositions are to induce tumor-specific T-cell responses and direct killing of tumor cells in subjects in need thereof.
Bibliography:Application Number: CN20248012169