用于抗体耦合的改良型连接符-负载物、医药组合物、及其应用

本揭露提供一种连接符-负载物复合体，其包含生物正交基团及亲水基团。用于抗体耦合的该改良型连接符-负载物以及改良的抗体药物复合体(ADC)表现出在血液循环中更高的稳定性，并且在目标细胞表现出增强的药物递送与药物释放效率。本揭露还涉及针对数种抗原标靶(例如TROP2、HER2、Nectin-4等)的抗体及其抗原结合片段，以及包含ADC的医药组合物。本揭露亦描述使用抗体药物复合体治疗病态状况之受试者的方法。 The present disclosure provides linker-payload conjugates including a bioorthogonal group and a h...

Full description

Saved in:
Bibliographic Details
Format Patent
LanguageChinese
Published 12.09.2025
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:本揭露提供一种连接符-负载物复合体，其包含生物正交基团及亲水基团。用于抗体耦合的该改良型连接符-负载物以及改良的抗体药物复合体(ADC)表现出在血液循环中更高的稳定性，并且在目标细胞表现出增强的药物递送与药物释放效率。本揭露还涉及针对数种抗原标靶(例如TROP2、HER2、Nectin-4等)的抗体及其抗原结合片段，以及包含ADC的医药组合物。本揭露亦描述使用抗体药物复合体治疗病态状况之受试者的方法。 The present disclosure provides linker-payload conjugates including a bioorthogonal group and a hydrophilic moiety. The improved linker-payloads for antibody conjugation and improved antibody drug conjugates (ADCs) exhibit greater stability in blood circulation and enhanced drug delivery and drug release efficiencies in target cells. The present disclosure also relates to antibodies and antigen-binding fragments thereof for several antigen targets (e.g. TROP2, HER2, Nectin-4, etc.), as well as pharmaceutical compositions including ADCs. Also described herein are methods of using ADCs for treatment of subjects associated with pathological conditions.
Bibliography:Application Number: CN20248010809