川芎嗪衍生物及其制备方法与用途

本发明提供一种结构新颖的川芎嗪衍生物及其组合物，在体外对神经元细胞损伤具有明显的保护作用，同时对体内氧化应激具有明显的抑制作用。同时本发明提供的化合物可以显著降低持久性局部脑缺血造成的脑损伤，显著减少脑梗死面积，抑制脑水肿，没有明显的致畸毒性，适宜开发为保护神经细胞、心血管疾病等多种疾病的药物。#imgabs0# The ligustrazine derivative with a novel structure and the composition thereof provided by the invention have an obvious protection effect on...

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Bibliographic Details
Format Patent
LanguageChinese
Published 02.09.2025
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:本发明提供一种结构新颖的川芎嗪衍生物及其组合物，在体外对神经元细胞损伤具有明显的保护作用，同时对体内氧化应激具有明显的抑制作用。同时本发明提供的化合物可以显著降低持久性局部脑缺血造成的脑损伤，显著减少脑梗死面积，抑制脑水肿，没有明显的致畸毒性，适宜开发为保护神经细胞、心血管疾病等多种疾病的药物。#imgabs0# The ligustrazine derivative with a novel structure and the composition thereof provided by the invention have an obvious protection effect on neuronal cell injury in vitro and have an obvious inhibition effect on oxidative stress in vivo. Meanwhile, the compound provided by the invention can significantly reduce brain injury caused by persistent local cerebral ischemia, significantly reduce the area of cerebral infarction and inhibit encephaledema, has no obvious teratogenic toxicity, and is suitable for being developed into drugs for protecting nerve cells, cardiovascular diseases and other diseases. # imgabs0 #
Bibliography:Application Number: CN202510604671