Methods of treating immune thrombocytopenia in subjects suffering from cognitive impairment by administering rizobrutinib

• Main Authors: DACKER ANDREAS, KHAN UZMA
• Format: Patent
• Language: Chinese; English
• Published: 15.07.2025
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed is a method for treating immune thrombocytopenia in a subject suffering from cognitive impairment, the method comprising administering a compound selected from the group consisting of (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl) pyrazolo [3, 4-b] pyrimidine-2-ketone, a compound selected from the group consisting of (R)-2-[3-[4-amino-3-(2-fluoro-4- The present invention relates to at least one compound selected from the group consisting of 4-(4-(4-(4-oxetan-3-yl) piperazine-1-yl) penta-2-enenitrile (rizobrutinib) and pharmaceutically acceptable salts thereof, in particular, 4-(4, 4-d) pyrimidin-1-yl) piperidin-1-carbonyl)-4-methyl-4-[4-(oxetan-3-yl) piperazine-1-yl] penta-2-enenitrile (rizobrutinib). 公开了用于治疗患有认知损害的受试者中的免疫性血小板减少症的方法，所述方法包括施用选自(R)-2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁-3-基)哌嗪-1-基]戊-2-烯腈(利扎鲁替尼)及其药学上可接受的盐的至少一种化合物。