Combined marker for predicting intrauterine adhesion after abortion curettage, kit and application

• Main Authors: FANG LING, XU SHIQIAN, WANG YANGYANG, ZHANG SONGYING, JIANG LINGLING
• Format: Patent
• Language: Chinese; English
• Published: 15.07.2025
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention provides a combined marker for predicting intrauterine adhesion after abortion curettage, a kit and application, and belongs to the technical field of biological detection. The method comprises the following steps: prospectively collecting macrophages of decidua of a subject, wherein the subject is in Damp; the method comprises the following steps of: selecting a non-IUA group and an IUA group according to B ultrasonic follow-up visit results of two months after operation, and analyzing gene differential expression of macrophages of the two groups of subjects, difference of intrauterine microbiota and change of serum metabolites to finally obtain a method capable of accurately predicting intrauterine adhesion after abortion curettage operation. According to the method, the model efficiency of predicting intrauterine adhesion after abortion curettage is as high as 97.8%, and the method has the advantages of being low in cost and simple and rapid in detection method and has a large application pro