Purple truffle exosome for improving athletic ability and intestinal flora composition of acute sleep deprivation mouse

• Main Authors: SUN WENLONG, TANG XUE, LU NAIYAN, ZHAO HAOTIAN
• Format: Patent
• Language: Chinese; English
• Published: 02.05.2025
• Subjects: FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention discloses a perigord truffle exosome for improving the athletic ability and intestinal flora composition of an acute sleep deprivation mouse, and belongs to the field of biomedicine. According to the application, the perigord truffle exosome is used on a mouse acute sleep deprivation inducing model, and the application of the perigord truffle exosome in treating motor ability and intestinal injury after acute sleep deprivation is discussed. Mouse athletic ability, energy metabolism, inflammatory factors in serum, oxidative stress in liver, and Hamp in ileum tissue; e staining, expression of tight junction protein and determination of indexes such as intestinal flora and the like find that the perigord truffle exosome can effectively improve the athletic ability and the intestinal flora after acute sleep deprivation. 本发明公开了黑松露外泌体改善急性睡眠剥夺小鼠的运动能力和肠道菌群组成，属于生物医学领域。本发明在诱导小鼠急性睡眠剥夺模型上使用黑松露外泌体，探讨本发明中黑松露外泌体对于治疗急性睡眠剥夺后的运动能力和肠道损伤中的用途。通过小鼠运动能力、能量代谢、血清中的炎症因子、肝脏中的氧化应激、回肠组织的H&E染色和紧密连接蛋白的表达以及肠道菌群等指标的测定，发现该黑松露外泌体