Methods of treating recurrent epithelioid sarcoma using bispecific anti-MUC16anti-CD3 antibodies alone or in combination with anti-PD-1 antibodies

• Main Author: HERMONT BARCELOS GONCALVES PABLO
• Format: Patent
• Language: Chinese; English
• Published: 21.03.2025
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides methods for treating, reducing the severity or inhibiting the growth of cancer (e.g., recurrent epithelioid sarcoma). The methods of the invention comprise administering to a subject in need thereof a therapeutically effective amount of a bispecific antibody that specifically binds mucoprotein 16 (MUC16) and CD3, either alone or in combination with a therapeutically effective amount of an antibody that specifically binds to the Programmed Death 1 (PD-1) receptor or an antigen-binding fragment thereof. 本发明提供了用于治疗癌症(例如，复发性上皮样肉瘤)、降低其严重性或抑制其生长的方法。本发明的方法包括向有需要的受试者单独施用或与治疗有效量的特异性结合至程序性死亡1(PD-1)受体的抗体或其抗原结合片段组合施用治疗有效量的特异性结合粘蛋白16(MUC16)和CD3的双特异性抗体。