Methods of treating multiple myeloma using BCL-2 inhibitors

• Main Authors: LI SHURAN, HU NAN, SONG XIAOMIN, CRESCENZO ROMUALDO
• Format: Patent
• Language: Chinese; English
• Published: 07.03.2025
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides for the use of a Bcl-2 inhibitor, in particular, 2-((1H-pyrrolo [2, 3-b] pyridin-5-yl) oxy)-N-((4-(((1r, 4r)-4-hydroxy-4-methylcyclohexyl) methyl) amino)-3-nitrophenyl) sulfonyl)-4-(2-((S)-2-(2-isopropylphenyl) pyrrolidin-1-yl)-7-azaspiro [3.5] non-7-yl) benzamide, or a pharmaceutically acceptable salt thereof, in particular, a pharmaceutically acceptable salt thereof. The present invention relates to methods of treating multiple myeloma in a subject, or in combination with dexamethasone. 本公开提供了用Bcl-2抑制剂，特别是2-((1H-吡咯并[2,3-b]吡啶-5-基)氧基)-N-((4-(((1r,4r)-4-羟基-4-甲基环己基)甲基)氨基)-3-硝基苯基)磺酰基)-4-(2-((S)-2-(2-异丙基苯基)吡咯烷-1-基)-7-氮杂螺[3.5]壬-7-基)苯甲酰胺或其药学上可接受的盐，或与地塞米松联合，以治疗受试者的多发性骨髓瘤的方法。