PHGDH inhibitors and their use in treatment of disseminated tumor cells

• Main Authors: FAN JIA, SUN YUNFAN, ZHANG ZEFAN, PENG HAIXIANG, ZHOU JIAN, WEN DONG
• Format: Patent
• Language: Chinese; English
• Published: 21.01.2025
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of biological medicine, and relates to a PHGDH inhibitor and application thereof in treating disseminated tumor cells. The invention discloses application of a PHGDH inhibitor or pharmaceutically acceptable salt, ester, isomer, prodrug, polymorphic substance or solvate thereof in preparation of a medicine for treating an object with and/or suspected to have DTC. Specifically provided are the use of a PHGDH inhibitor in the preparation of a medicament for treating a subject with and/or suspected of having DTC, a product comprising the PHGDH inhibitor, and the use thereof in combination with other treatments. The present invention also relates to a method of treating a subject with and/or suspected of having disseminated tumor cells (DTC) using the PHGDH inhibitors and pharmaceutically acceptable salts, esters, isomers, prodrugs, polymorphs, or solvates thereof. In addition, the invention further discloses application of the PHGDH and the biological effect of the PHGDH as a tr