Duckweed-based edible vaccines

• Main Authors: JIN YANLING, ZHAO HAI, TAN XIAO, WANG HONGNING, HE KAIZE, CHEN SHUANG
• Format: Patent
• Language: Chinese; English
• Published: 07.01.2025
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FODDER; FOODS OR FOODSTUFFS; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; TRAPPING; VINEGAR; WINE

The invention discloses an edible vaccine based on duckweed. Transgenic duckweed is used to orally deliver its expressed antigen to the intestinal tract, which stimulates the mucosal immune system of the intestinal tract to induce an immune response. The duckweed vaccine is characterized by inducing humoral immunity and mucosal immunity against an antigen in a subject eating the vaccine. 本发明公开了基于浮萍的可食用疫苗。转基因浮萍被用于将其表达的抗原口服递送至肠道，抗原刺激肠道的粘膜免疫系统诱导免疫反应。浮萍疫苗以在食用该疫苗的受试者中诱导针对抗原的体液免疫及粘膜免疫为特征。