MR-proADM as marker of extracellular volume status of subject

• Main Authors: VIGUE BERNARD, RAVYI-NIKOUGH HOMA
• Format: Patent
• Language: Chinese; English
• Published: 27.12.2024
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The present invention relates to MR-proADM as a marker of the extracellular volume status of a subject. In particular, the present invention relates to a method for determining an extracellular volume status of a subject. The method comprises determining, in a sample obtained from a subject, the level of a marker, i.e., proadrenomedullin (proADM), or a fragment thereof, preferably MR-proADM. Furthermore, the present invention relates to a method for in vitro diagnosis, risk stratification, therapy control and/or surgical control of a condition or medical condition in a subject wherein the extracellular volume status and salt retention in the subject are determined by the methods provided herein. Furthermore, the present invention relates to a kit and/or diagnostic device for performing the method provided herein. 本发明涉及作为对象的细胞外容量状态的标志物的MR-proADM。具体地，本发明涉及一种用于确定对象的细胞外容量状态的方法。所述方法包括在从对象获得的样品中确定标志物肾上腺髓质素原（proADM）或其片段、优选为MR-proADM的水平。此外，本发明涉及一种用于对象中的病症或医学病状的体外诊断、风险分层、疗法控制和/或手术控制的方法，其中通过本文中提供的方法确定所述对象的所述细胞外容量状态和盐潴留