Application of LDHA function-based biomarker in tumor diagnosis

• Main Authors: DING YUAN, WANG WEILIN, CHEN XIAO, MAO ZAICAI, BI YANLI, ZHANG SITONG
• Format: Patent
• Language: Chinese; English
• Published: 27.12.2024
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention provides an application of a modified LDHA S319 phosphorylated LDHA as a biomarker in preparation of a tumor diagnosis reagent. The invention further provides a kit capable of quantitatively or semi-quantitatively detecting the protein, and the kit contains the phosphorylated antibody capable of being specifically combined with LDHA S319. According to the application disclosed by the invention, by detecting the expression level of LDHA S319 phosphorylation, the tumor condition of a subject can be more effectively and preliminarily evaluated and predicted. The application of the invention is helpful for improving the diagnosis accuracy of tumors, and provides an important basis for early treatment of patients. The invention also provides an application of the LDHA S319 phosphorylated antibody in preparation of a tumor diagnosis kit. 本发明提供LDHA的修饰形式LDHA S319磷酸化作为生物标志物在制备肿瘤诊断试剂中的应用。本发明还提供可定量或半定量检测蛋白质的试剂盒，内含可特异性结合LDHA S319磷酸化的抗体。本发明所述的应用通过检测LDHA S319磷酸化的表达水平，能够更有效地对受试者患肿瘤的情况进行初步评估和预测。本发明的应用将有助于提高肿瘤的诊