Method for detecting macrophage population

• Main Authors: GENCHOU FLORENT, BRIOT, CAMILLA, AHOUDI, MIRIAM
• Format: Patent
• Language: Chinese; English
• Published: 19.07.2024
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; NEW BREEDS OF ANIMALS; PHYSICS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; TESTING; TRAPPING

Methods of detecting a population of macrophages in a sample are provided, comprising detecting and/or determining expression of Cdh5 in macrophages in a sample. Also disclosed are kits for detecting and/or isolating and/or depleting a macrophage population, methods of depleting a macrophage population, methods of improving the health of an obese and/or overweight subject, methods of determining the risk of obesity and/or metabolic impairment associated with obesity in a subject, and animal models thereof. 提供了检测样品中巨噬细胞群的方法，包括检测和/或确定样品中巨噬细胞中Cdh5的表达。还公开了用于检测和/或分离和/或耗尽巨噬细胞群的试剂盒、耗尽巨噬细胞群的方法、改善肥胖和/或超重受试对象的健康的方法、确定受试者肥胖和/或与肥胖相关的代谢损伤风险的方法，以及其动物模型。