Subject-guest compound for treating platinum-resistant ovarian cancer as well as preparation method and application of subject-guest compound

• Main Author: ZHAO GE
• Format: Patent
• Language: Chinese; English
• Published: 12.07.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a subject-guest compound and a preparation method thereof, and application of the subject-guest compound in treatment of platinum-resistant ovarian cancer. The subject-guest compound is prepared from a subject compound and a guest compound in a specific ratio by a specific method, and the prepared subject-guest compound has the characteristics of being basically non-toxic to normal cells of a human body and being capable of specifically killing platinum-resistant ovarian cancer. Furthermore, it is found that the subject-object compound prepared by the invention can overcome tumor drug resistance and realize targeted treatment of drug-resistant tumors or drug-resistant cancers through a programmed necrosis approach, and has a good clinical application prospect. 本发明提供了一种主客体复合物及其制备方法，以及它们在治疗铂耐药卵巢癌方面的应用。将主体化合物与客体化合物在特定的比例下，以特定的方法制备被主客体复合物，制备所得主客体复合物具有对人体正常细胞基本无毒，但能特异性杀伤铂耐药卵巢癌的特性。并且进一步发现，本发明所制备的主客体复合物，可以通过程序性坏死途径，克服肿瘤耐药，实现耐药肿瘤或耐药癌症的针对性治疗，具有良好的临床应用前景。