Combination therapy of SETD2 inhibitors

• Main Authors: RAIMONDI MARIA ALESSANDRA, COSMOPOULOS, CATHERINE, LOUISE, TOTMAN JENNIFER ANNE, MOTWANI, VINAY, BRACH DOROTHY, DRANSFIELD DANIEL T
• Format: Patent
• Language: Chinese; English
• Published: 29.03.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides SETD2 protein inhibitors, and methods, uses, compositions, and kits for treating a disease, disorder, or condition in a subject with a SETD2 protein inhibitor and a second therapeutic agent, wherein the second therapeutic agent comprises one or more BTK inhibitors, one or more anti-CD20 monoclonal antibodies, one or more alkylating agents, one or more topoisomerase II inhibitors, and one or more catharanthus alkaloids, one or more platinum drugs, one or more nucleoside anti-cancer drugs, one or more PI3K inhibitors, one or more CDK4/6 inhibitors, one or more CARM1 inhibitors, one or more DNA damage repair enzyme inhibitors, one or more SYK inhibitors, or one or more MEK inhibitors, or a combination thereof. 本公开提供了SETD2蛋白抑制剂，以及用SETD2蛋白抑制剂和第二治疗剂治疗受试者的疾病、障碍或病症的方法、用途、组合物和试剂盒，其中第二治疗剂包括一种或多种BTK抑制剂、一种或多种抗-CD20单克隆抗体、一种或多种烷化剂、一种或多种拓扑异构酶II抑制剂、一种或多种长春花生物碱，一种或多种铂类药物、一种或多种核苷类抗癌药物、一种或多种PI3K抑制剂、一种或多种CDK4/6抑制剂、一种或多种CARM1抑制剂、一种或多种DNA损伤修复酶的抑制剂、一种或多种SYK抑制剂、或一种或多种MEK抑制剂，或它们的组合。